Synthesis, Characterization and Antioxidant Studies of some Transition Metal Complexes with Chalcone Derivative (2-Chloroacetophenone) and 2-Hydroxybenzaldehyde

Abstract

Chalcone derivatives and their complexes have been attracting researcher’s attention due to their numerous numbers of biological activities and their uses as alternative inexpensive and synthetic compounds for treating metabolic diseases. Hence, this research focuses on the synthesis of chalcone derivatives complexes, characterization and their antioxidant activities evaluation. The complexes were prepared by claisen-schmidt condensation using Co(II), Ni(II) and Zn(II) chloride salts and were characterized using melting point/decomposition temperatures, solubility test, conductivity measurement, FT-IR and antioxidant evaluation was conducted using 1,1-diphenyl-2-dipicrylhydrazyl radical assay. The antioxidant activity of the cobalt complex was found to have better scavenging activity with IC50 of 7.89µg/ml than that of the standard vitamin C control with 10.77µg/ml. Similarly, zinc complex shows a better scavenging activity with an IC50 of 10.12µg/ml and nickel complex was the one with lowest scavenging activity against the standard vitamin C control with and IC50 of 29.91µg/ml. From the results obtained, it can be concluded that the chalcone derivatives complexes shows strong activity on free radical scavenging effect and the characterization of the compounds confirmed that the complexes were successfully synthesized.